ABOUT US

Hello, I am Nirali here and together with me here is my lovely companions, Haidir, Reza, Ayu and Hong. We all currently further our study in Bachelor of Pharmacy.

We all are from different unique hometown. Haidir, our team leader is from Kuala Lipis, Pahang while Reza is from Kalimantan followed by Hong who is raise up in Sabah, Ayu from Palembang, Indonesia who is from and myself from Malacca.

Together of us are impatient to explore the unique journey of univercity and endure journey to be a future pharmacist.

PROTEIN DATABASE                                                                                                             http://www.rcsb.org/pdb/home/home.do

The PDB (Protein Data Bank) archive is a repository of atomic coordinates and other information describing proteins and other important biological macromolecules. The PDB give the information of three dimensional structural biology. 

Select which one of the topic you want, then start to exploring. The Structural View of Biology interface starts with key topic categories and subcategories that drill down to individual molecules.

The PDB also share a video to help you to understanding about the 3D shape and the function of macromolecules.

DRUG ADVERSE REACTIONS TARGET DATABASE

A database for encouraging the quest for medication antagonistic response target. It contains data about known medication antagonistic response targets, capacities and properties. Related references are likewise included. For example :

Protein Name ; Cholinesterase

Adverse Effect : Inhibiton of cyclophosphamide is decreases or moderates cocaine digestion system, along these lines expanding and/or delaying its belongings and expanding the danger of toxicity.

Another Adverse Effect : Sickness, Vomiting, Diarrhea, Dizziness, Asthenia, Anorexia, Organophosphorus (operation) pesticides danger, Painful neuropathy, Cardiovascular, Cerebrovascular, Renal brokenness, Early passing

This database has allowed pharmacist to enhance their information more widely and precisely.

THERAPEUTIC TARGET DATABASE

Therapeutic Target Database is a database to provide information about the known and explored therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. Also included in this database are links to relevant databases containing information about target function, sequence, 3D structure, ligand binding properties, enzyme nomenclature and drug structure, therapeutic class, clinical development status. All information provided are fully referenced.

Statistics of the database

Therapeutic Target Database allows us to explore therapeutic target information by using search whole database as shown below: 

From the search whole database, I have found some useful information about the drugs used to treat Alzheimer's disease. One of the drugs is Rivastigmine. Rivastigmine is  a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease. The drug can be administered orally or via a transdermal patch; the latter form reduces the prevalence of side effects, which typically include nausea and vomiting. The drug is eliminated through the urine, and appears to have relatively few drug-drug interactions.

Structure of drug Rivastigmine (Trade name: Exelon)
Indication: Alzheimer's disease
Therapeutic class: Parasympathomimetics
Target: Acetylcholinesterase

Here is a video about the information of drug Rivastigmine:

POTENTIAL DRUG TARGET DATABASE

PDTD

PDTD is a web-accessible protein database for in silico target identification. It currently contains more than 1100 protein entries with 3D structures presented in the Protein Data Bank. The data are extracted from the literatures and several online database such as TTD, DrugBank and Thomson Pharma. The database covers diverse information of more than 830 known or potential drug targets, including protein and active sites structure in both PDB and mol2 formats, related diseases, biological functions as well as associated regulating pathways. Each target is categorized by both nosology and biochemical function. PDTD supports keyword search function, such as PDB ID, target name, and disease name. Data set generated by PDTD can be viewed with the plug-in of molecular visualization tools and also can be downloaded freely. Remarkably, PDTD is specially designed for target identification. In conjunction with TarFisDock, PDTD can be used to identify binding proteins for small molecules. The results can be downloaded in the form of mol2 file with the binding pose of the probe compound and a list of potential binding targets according to their ranking scores. 

PDTD serves as a comprehensive and unique repository of drug targets. Integrated with TarFisDock, PDTD is a useful resource to identify binding proteins for active compounds or existing drugs. Its potential applications include in silico drug target identification, virtual screening, and the discovery of the secondary effects of an old drug (i.e. new pharmacological usage) or an existing target (i.e. new pharmacological or toxic relevance), thus it may be a valuable platform for the pharmaceutical researchers. PDTD is available online at http://www.dddc.ac.cn/pdtd/ 

DRUG POTENCY DATABASE

DPD

DPD is a relational database focusing on providing activity information of drugs, clinical trial compounds and experimental agents directed at their corresponding therapeutic targets. Also included in this database are links to relevant databases containing information about target function, sequence, 3D structure, ligand biding properties, enzyme nomenclature and drug structure, therapeutic class, clinical development status. All information provided are fully referenced. 

Currently this database contains 5000 records of activity for around 3000 compounds directed at about 500 targets. Near 300 compounds in DPD have already approved or been in the clinical trial stage.  

DRUG BANK DATABASE

Drug Bank Database

Drug bank database is biological database which is one of crucial development for our modern century. I have manage to find some useful information about Benzylpenicilin. Benzylpenicillin (Penicillin G) is limited range anti-microbial used to treat diseases brought on by vulnerable microorganisms. It is a characteristic penicillin anti-infection that is managed intravenously or intramuscularly because of poor oral ingestion. Penicillin G might likewise be utilized as a part of a few bodies of evidence as prophylaxis against defenseless creatures.
The structure of Benzylpenicillin is
The name "penicillin" can either allude to a few variations of penicillin accessible, or to the gathering of anti-toxins got from the penicillins. Penicillin G has in vitro action against gram-positive and gram-negative high-impact and anaerobic microorganisms. The bactericidal movement of penicillin G results from the hindrance of cell divider amalgamation and is intervened through penicillin G tying to penicillin tying proteins (PBPs). Penicillin G is stable against hydrolysis by an assortment of beta-lactamases, including penicillinases, and cephalosporinases and augmented range beta-lactamases.

HUMAN SYNC DATABASE

Human cync database is a bioinformatics database that describes human metabolic pathways and the human genome. It is also an encyclopedic reference especially on human metabolic pathways.

The database provides the user with an extended dimension for functional analysis of human being
( Homo sapiens ) at the genomic level.

As an example, Human cync database has tools for analysis of human metabolomics and gene-expression data.

Example of specific database of Homo sapiens